| Description | MMV008138 inhibits the growth of P. falciparum Dd2 strain (IC50 of 250 nM). |
| In vitro | MMV008138 targets IspD enzymes in the MEP pathway of P. falciparum[1] |
| Target activity | PfIspD:44 nM |
| molecular weight | 361.22 |
| Molecular formula | C18H14Cl2N2O2 |
| CAS | 1679333-73-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 125 mg/mL (346.05 mM), Sonication is recommended. |
| References | 1. Ghavami M, et al. Biological Studies and Target Engagement of the 2- C-Methyl-d-Erythritol 4-Phosphate Cytidylyltransferase (IspD)-Targeting Antimalarial Agent (1 R,3 S)-MMV008138 and Analogs. ACS Infect Dis. 2018 Apr 13;4(4):549-559. 2. Yao ZK, et al. Determination of the active stereoisomer of the MEP pathway-targeting antimalarial agent MMV008138, and initial structure-activity studies. Bioorg Med Chem Lett. 2015 Apr 1;25(7):1515-9. |