| Description | MMPIP hydrochloride is a selective antagonist of allosteric mGluR7. MMPIP hydrochloride can be used in research on the roles of mGluR7 on central nervous system functions. |
| In vitro | 在共表达大鼠mGluR7与Gα15的CHO细胞中，MMPIP hydrochloride 抑制L-(+)-2-氨基-4-磷酸丁酸(L-AP4; 0.5 mM)诱导的细胞内Ca2+动员，其IC50为26 nM。MMPIP hydrochloride 还能抗拮抗L-AP4诱导的cAMP积累抑制作用，具有610 nM的IC50。在表达大鼠mGluR7的CHO细胞中，MMPIP hydrochloride 抑制了L-AP4诱导的福斯可林刺激cAMP积累的抑制[1]。 |
| In vivo | MMPIP hydrochloride在神经病理小鼠中缓解疼痛，正常化情感和认知行为。通过提高选择准确性，MMPIP hydrochloride (10 mg/kg; i.p.) 可逆转MK-801 (0.1 mg/kg) 引起的认知障碍。此外，MMPIP hydrochloride (10 mg/kg) 降低了声音惊跳反应的幅度，并显著增强了前脉冲引起的声音惊跳反应抑制（高达控制的137%）[2]。 |
| Synonyms | MMPIP hydrochloride (479077-02-6 Free base) |
| molecular weight | 369.8 |
| Molecular formula | C19H16ClN3O3 |
| CAS | 1215566-78-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 3.7 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Gentaroh Suzuki, et al. In vitro pharmacological characterization of novel isoxazolopyridone derivatives as allosteric metabotropic glutamate receptor 7 antagonists. J Pharmacol Exp Ther. 2007 Oct;323(1):147-56. 2. Paulina Cieślik, et al. Negative Allosteric Modulators of mGlu 7 Receptor as Putative Antipsychotic Drugs. Front Mol Neurosci. 2018 Sep 20;11:316. |