| Description | MMP-3 Inhibitor acetate is a cell-permeable and potent inhibitor of human MMP-3. |
| In vitro | MMP3抑制剂1对MMP-1、MMP-2、MMP-9和MMP-14的抑制作用，其IC50分别为14000、529、2420和20100 nM[1]。 |
| In vivo | MMP-3 Inhibitor 是一种可渗透细胞的p-甲氧基磺酰胺D-亮氨酸含有的羟胺化合物，作为一种强效的人类MMP-3（stromelysin; Ki = 23 nM）和小鼠巨噬细胞金属弹性蛋白酶（MME/MMP-12; IC50 = 13 nM）抑制剂。该化合物通过结合MMP活性位点的Zn2+ [2] [3]发挥作用。 |
| Synonyms | MMP-3 Inhibitor acetate(158841-76-0 Free base) |
| molecular weight | 746.83 |
| Molecular formula | C29H50N10O11S |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Gavin A Whitlock, et al. A novel series of highly selective inhibitors of MMP-3. Bioorg Med Chem Lett. 2007 Dec 15;17(24):6750-3. 2. Ai Ing Lim, et al. Distinct role of matrix metalloproteinase-3 in kidney injury molecule-1 shedding by kidney proximal tubular epithelial cells. Int J Biochem Cell Biol. 2012 Jun;44(6):1040-50. 3. Ran Gao, et al. Heterogeneous nuclear ribonucleoprotein K (hnRNP-K) promotes tumor metastasis by induction of genes involved in extracellular matrix, cell movement, and angiogenesis. J Biol Chem. 2013 May 24;288(21):15046-56. |