| Description | MMP-12 Inhibitor is a selective inhibitor of MMP-12 with IC50s of 2, 160, 320, and 22.3 nM for human, mouse, rat, and sheep MMP-12. |
| In vitro | MMP-12 Inhibitor 对人体MMP-3、MMP-13和MMP-14的活性较弱，其半抑制浓度(IC50)分别为351、120和1100 nM[1]。 |
| In vivo | 在小鼠中，MMP-12 Inhibitor（5 mg/kg，p.o.）能有效减轻rhMMP-12引起的肺部炎症反应，降低率超过50%[1]。 |
| Synonyms | MMP12, MMP408 |
| molecular weight | 420.44 |
| Molecular formula | C19H20N2O7S |
| CAS | 1258003-93-8 |
| Storage | store at low temperature|Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (118.9 mM) |
| References | 1. Wei Li, et al. A Selective Matrix Metalloprotease 12 Inhibitor for Potential Treatment of Chronic Obstructive Pulmonary Disease (COPD): Discovery of (S)-2-(8-(Methoxycarbonylamino)dibenzo[b,d]furan-3-sulfonamido)-3-methylbutanoic acid (MMP408). Journal of Medicinal Chemistry 2009 52 (7), 1799-1802 |
| Citations | 1. Li T, Mao N, Xie Z, et al.Paeoniflorin mitigates MMP-12 inflammation in silicosis via Yang-Yin-Qing-Fei Decoction in murine models.Phytomedicine.2024: 155616. |