| Description | MMK 1 acetate is an agonist of formyl peptide receptor 2 (FPR2), which was previously known as formyl peptide receptor-like 1 (FPRL1) [1]. |
| In vitro | MMK1在表达人类FPR2和Gα16的CHO细胞中诱导钙通量(EC50 = 10,000 nM)。它以浓度依赖的方式促进了分离的人类外周血单核细胞和中性粒细胞的趋化作用[2]。MMK1 (10 µM)增加了在分离的人类单核细胞中产生的促炎细胞因子IL-1β和IL-6的生成[3]。 |
| In vivo | 小鼠脑室内注射MMK1（100 pmol/只小鼠）能增加其在高架十字迷宫开放臂中的活动时间百分比，表明MMK1具有类似抗焦虑的活性 [3]。 |
| Synonyms | MMK 1 acetate(271246-66-3 free base) |
| molecular weight | 1671.01 |
| Molecular formula | C77H127N19O20S |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. C Klein, et al.Identification of surrogate agonists for the human FPRL-1 receptor by autocrine selection in yeastNat. Biotechnol.16(13)1334-1337(1998). 2. J Y Hu, et al. Synthetic peptide MMK-1 is a highly specific chemotactic agonist for leukocyte FPRL1J. Leukoc. Biol.70(1)155-161(2001). 3. Hui Zhao, et al. Rubimetide, humanin, and MMK1 exert anxiolytic-like activities via the formyl peptide receptor 2 in mice followed by the successive activation of DP1, A2A, and GABAA receptors. Peptides. 2016 Sep;83:16-20. |