| Description | MLT-747 is an effective and allosteric inhibitor of MALT1. It binds MALT1 in the allosteric Trp580 pocket (IC50: 14 nM). |
| In vitro | MLT-747 (0-20 μM) stabilizes cellular MALT1-W580S (EC50: 314 nM). |
| Target activity | MALT1:14 nM |
| molecular weight | 478.33 |
| Molecular formula | C20H21Cl2N7O3 |
| CAS | 2097853-86-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313. |