| Description | ML359 is a protein disulfide isomerase inhibitor. |
| In vitro | ML359被证明是PDI的特异性抑制剂。在三种人类细胞系中，ML359未显示出细胞毒性，并且在体外抑制血小板聚集方面表现出一定活性。ML359将提供更多关于PDI在血小板功能中机制的理解。它也可能促成一个新类别的抗血栓化合物的开发，这将确立PDI作为合适的靶标。 |
| Target activity | Protein disulfide isomerase:250 nM (IC50) |
| Synonyms | ML-359, ML 359 |
| molecular weight | 417.93 |
| Molecular formula | C23H28ClNO4 |
| CAS | 1069858-99-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 84 mg/mL (200.99 mM) Ethanol: 84 mg/mL (200.99 mM) |
| References | 1. Khodier C, VerPlank L, Nag PP, Pu J, Wurst J, Pilyugina T, Dockendorff C, Galinski CN, Scalise AA, Passam F, van Hessem L, Dilks J, Kennedy DR, Flaumenhaft R, Palmer MAJ, Dandapani S, Munoz B, Schrieber SL. Identification of ML359 as a Small Molecule Inhibitor of Protein Disulfide Isomerase. 2013 Apr 12 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from http://www.ncbi.nlm.nih.gov/books/NBK189925/ PubMed PMID: 24624466. |