| Description | ML328 is a potent and selective inhibitor of bacterial AddAB(IC50 = 1.0 μM) and RecBCD(IC50 = 4.8 μM) helicase-nucleases. |
| In vitro | 探针ML328在常温下以10μM浓度于PBS溶液中的半衰期超过48小时。在6小时的孵育期内，即使向溶液中额外添加50μM的谷胱甘肽，探针的液相色谱峰消失情况也不受影响[1]。 |
| Target activity | RecBCD:4.8 μM, AddAB:1.0 μM |
| molecular weight | 506.5 |
| Molecular formula | C22H21F3N6O3S |
| CAS | 634175-34-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (98.72 mM) |
| References | 1. Bannister TD, et al. ML328: A Novel Dual Inhibitor of Bacterial AddAB and RecBCD Helicase-nuclease DNA Repair Enzymes. 2012 Dec 17 [updated 2013 Apr 5]. In: Probe Reports from the NIH Molecular Libraries Program [Internet]. |