| Description | ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50= 1.1 μM in a reporter assay).1It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50= 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+T cells into Th17 T helper cells. |
| Target activity | RORγ:1.1 μM |
| molecular weight | 441.52 |
| Molecular formula | C25H31NO6 |
| CAS | 1334526-14-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 18.33 mg/mL (41.52 mM), Sonication is recommended. |
| References | 1. Huh, J.R., Englund, E.E., Wang, H., et al.Identification of potent and selective diphenylpropanamide RORγ inhibitorsACS Med. Chem. Lett.4(1)79-84(2013) |