| Description | MK771 is a therapeutic agent and an analog of the Thyrotropin Releasing Hormone (TRH). TRH and its analogs may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. |
| Synonyms | MK-771, MK 771 |
| molecular weight | 394.45 |
| Molecular formula | C16H22N6O4S |
| CAS | 66537-55-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hutson PH, Semark JE, Middlemiss DN. The TRH analogue MK-771, increases acetylcholine release in hippocampus but not striatum of the conscious rat. Neurosci Lett. 1990 Aug 14;116(1-2):149-55. PubMed PMID: 2124336. 2. Sills MA, Jacobowitz DM. Chronic administration of desipramine or nialamide decreases wet-dog shakes in rats produced by the TRH-analog MK-771. Brain Res. 1987 Jan 13;401(1):195-9. PubMed PMID: 3101979. 3. Horita A, Carino MA, Lai H. Preliminary studies on the effects of a TRH analog, MK-771, in an animal model of Alzheimer's disease. Proc West Pharmacol Soc. 1987;30:57-8. PubMed PMID: 3114755. 4. Simasko SM, Horita A. Treatment of rats with the TRH analog MK-771. Down-regulation of TRH receptors and behavioral tolerance. Neuropharmacology. 1985 Feb;24(2):157-65. PubMed PMID: 2986033. |