| Description | MK-8719 is a highly potent and selective inhibitor of O-GlcNAcase (OGA) (hOGA, Ki=7.9 nM) . |
| In vivo | MK-8719具有出色的固有效能和选择性，高中枢神经系统(CNS)暴露度，高Papp，良好的代谢稳定性，优良的药代动力学特性，以及强效的药效动力学反应[1]。 |
| Target activity | O-GlcNAcase (OGA):ki:7.9 nM |
| molecular weight | 268.28 |
| Molecular formula | C9H14F2N2O3S |
| CAS | 1382799-40-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (186.37 mM) |
| References | 1. Selnick HG, et al. Discovery of MK-8719, a Potent O-GlcNAcase Inhibitor as a Potential Treatment for Tauopathies. J Med Chem. 2019 Sep 29. |
| Citations | 1. Wang N, Yu M, Fu Y, et al. Blocking ATM Attenuates SKOV3 Cell Proliferation and Migration by Disturbing OGT/OGA Expression via hsa-miR-542-5p. Frontiers in Oncology. 2022.12 |