| Description | MK 410 is an indomethacin analogue and anti-inflammatory agent that induces changes in the immune system by inhibiting plasma neutral protease activity. |
| Synonyms | MK-410, MK410 |
| molecular weight | 369.48 |
| Molecular formula | C21H23NO3S |
| CAS | 40738-05-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Van Dyke K, Peden D, Van Dyke C, Jones G, Castranova V, Ma J. Inhibition by nonsteroidal antiinflammatory drugs of luminol-dependent human-granulocyte chemiluminescence and [3H]FMLP binding. Effect of sulindac sulfide, indomethacin metabolite, and optical enantiomers (+) and (-) MK830. Inflammation. 1982 Mar;6(1):113-25. PubMed PMID: 7085041. 2. Lassmann G, Curtis J, Liermann B, Mason RP, Eling TE. ESR studies on reactivity of protein-derived tyrosyl radicals formed by prostaglandin H synthase and ribonucleotide reductase. Arch Biochem Biophys. 1993 Jan;300(1):132-6. PubMed PMID: 8380961. 3. Hart DA, Mannerfeldt J, Babins E. Treatment of mice with indomethacin leads to the appearance of a 125,000 dalton plasma protein with the characteristics of an acute phase reactant. J Clin Lab Immunol. 1987 Jun;23(2):83-90. PubMed PMID: 2442392. 4. Markey CM, Alward A, Weller PE, Marnett LJ. Quantitative studies of hydroperoxide reduction by prostaglandin H synthase. Reducing substrate specificity and the relationship of peroxidase to cyclooxygenase activities. J Biol Chem. 1987 May 5;262(13):6266-79. PubMed PMID: 3106353. |