| Description | MK-386 is a potent and selective inhibitor of human type-1 5alpha-reductase. |
| Synonyms | MK 386, MK386 |
| molecular weight | 415.69 |
| Molecular formula | C28H49NO |
| CAS | 158493-17-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bühler P, Fischer T, Wolf P, Gierschner D, Schultze-Seemann W, Wetterauer U, Elsässer-Beile U. Comparison of gene expression in LNCaP prostate cancer cells after treatment with bicalutamide or 5-alpha-reductase inhibitors. Urol Int. 2010;84(2):203-11. doi: 10.1159/000277600. Epub 2010 Mar 4. PubMed PMID: 20215827. 2. Festuccia C, Gravina GL, Muzi P, Pomante R, Angelucci A, Vicentini C, Bologna M. Effects of dutasteride on prostate carcinoma primary cultures: a comparative study with finasteride and MK386. J Urol. 2008 Jul;180(1):367-72. doi: 10.1016/j.juro.2008.02.036. Epub 2008 May 22. PubMed PMID: 18499161. 3. Liu S, Yamauchi H. Different patterns of 5alpha-reductase expression, cellular distribution, and testosterone metabolism in human follicular dermal papilla cells. Biochem Biophys Res Commun. 2008 Apr 18;368(4):858-64. doi: 10.1016/j.bbrc.2008.01.130. Epub 2008 Feb 5. PubMed PMID: 18258185. 4. Seiffert K, Seltmann H, Fritsch M, Zouboulis CC. Inhibition of 5alpha-reductase activity in SZ95 sebocytes and HaCaT keratinocytes in vitro. Horm Metab Res. 2007 Feb;39(2):141-8. PubMed PMID: 17326010. |