| Description | MK-2894 is a prostaglandin receptor 4 antagonist.MK-2894 has anti-inflammatory activity and may be used in the study of inflammation. |
| Target activity | EP4:0.56 nM (Ki), EP4:2.5 nM |
| Synonyms | MK 2894, MK2894 |
| molecular weight | 473.51 |
| Molecular formula | C25H22F3NO3S |
| CAS | 1006036-87-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (105.59 mM) H2O: < 1 mg/mL (Insoluble) |
| References | 1. Blouin M,et al. The discovery of 4-{1-[({2,5-dimethyl-4-[4-(trifluoromethyl)benzyl]-3-thienyl}carbonyl)amino]cyclopropyl}benzoic acid (MK-2894), a potent and selective prostaglandin E2 subtype 4 receptor antagonist. J Med Chem. 2010 Mar 11;53(5):2227-38. 2. Tijana Markovič, et al. Structural features of subtype-selective EP receptor modulators. Drug Discov Today. 2017 Jan;22(1):57-71. |