| Description | MK-1064 (Urokinase inhibitor 1) is a selective orexin 2 receptor antagonist (2-SORA). |
| Synonyms | Urokinase inhibitor 1, MK 1064 |
| molecular weight | 461.9 |
| Molecular formula | C24H20ClN5O3 |
| CAS | 1207253-08-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 0.1 mg/mL (insoluble) DMSO: 50 mg/mL (108.25 mM), Sonication is recommended. |
| References | 1. Roecker AJ et al. ChemMedChem. 2014 Feb;9(2):311-22. 2. Gotter AL et al. Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man. Sci Rep. 2016 Jun 3;6:27147. |