| Description | MK-0674 is an orally available, selective and potent cathepsin K inhibitor (IC50: 0.4 nM) that inhibits Cat B, Cat F, Cat L, and Cat S. It can be used in metabolism-related diseases. |
| In vitro | MK-0674 作为一种口服生物可利用的组织蛋白酶K抑制剂，能够作用于兔破骨细胞，IC50为 10 nM。 |
| Target activity | Cathepsin K:0.4 nM |
| molecular weight | 527.5 |
| Molecular formula | C26H27F6N3O2 |
| CAS | 887781-62-6 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Isabel E, et al. The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor. Bioorg Med Chem Lett. 2010 Feb 1;20(3):887-92. |