| Description | MJE3 is an inhibitor of phosphoglycerate mutase-1 (PGAM1), it displays antiproliferative effects in human breast cancer cells by inhibiting glycolysis. |
| Synonyms | MJE 3, MJE-3 |
| molecular weight | 600.71 |
| Molecular formula | C35H40N2O7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Schwaid AG, Cornella-Taracido I. Causes and Significance of Increased Compound Potency in Cellular or Physiological Contexts. J Med Chem. 2017 Aug 18. doi: 10.1021/acs.jmedchem.7b00762. [Epub ahead of print] PubMed PMID: 28820267. 2. Evans MJ, Morris GM, Wu J, Olson AJ, Sorensen EJ, Cravatt BF. Mechanistic and structural requirements for active site labeling of phosphoglycerate mutase by spiroepoxides. Mol Biosyst. 2007 Jul;3(7):495-506. Epub 2007 May 10. PubMed PMID: 17579775. 3. Evans MJ, Saghatelian A, Sorensen EJ, Cravatt BF. Target discovery in small-molecule cell-based screens by in situ proteome reactivity profiling. Nat Biotechnol. 2005 Oct;23(10):1303-7. Epub 2005 Oct 2. PubMed PMID: 16200062. |