| Description | MitoEbselen-2 is a radiation mitigator which reduces lipid hydroperoxides and prevents apoptotic cell death. When administered 24 hours postirradiation, MitoEbselen-2 was shown to increase the survival of mice exposed to whole body γ-irradiation. |
| Synonyms | MitoPeroxidase-2, MitoPeroxidase 2, MitoEbselen 2, MitoEbselen-2 |
| molecular weight | 656.01 |
| Molecular formula | C35H30ClN2O2PSe |
| CAS | 1638973-78-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H. Correction to "Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator". ACS Med Chem Lett. 2016 Jun 1;7(6):653-4. doi: 10.1021/acsmedchemlett.6b00212. eCollection 2016 Jun 9. PubMed PMID: 27326344; PubMed Central PMCID: PMC4910416. 2. Stoyanovsky DA, Jiang J, Murphy MP, Epperly M, Zhang X, Li S, Greenberger J, Kagan V, Bayır H. Design and Synthesis of a Mitochondria-Targeted Mimic of Glutathione Peroxidase, MitoEbselen-2, as a Radiation Mitigator. ACS Med Chem Lett. 2014 Nov 18;5(12):1304-1307. eCollection 2014 Dec 11. PubMed PMID: 25530831; PubMed Central PMCID: PMC4266336. |