| Description | Miglitol (BAY1099) is an alpha-Glucosidase Inhibitor with antihyperglycemic activity. |
| In vivo | D-cycloserine（DCS）在未预先暴露的情况下，有助于消除对光条件刺激（CS）的条件性冻结行为，但在条件化训练之前预先暴露于DCS会干扰在小鼠中消除行为的促进效应。[1] DCS对NMDA受体复合物中的甘氨酸调节位点有高亲和力，以剂量依赖的方式调节记忆处理。DCS还有助于加速衰老小鼠的记忆保持，在这种小鼠中，学习和记忆的障碍随年龄增长而增加。[2] DCS表现出加速恐惧消退的特性，但在与生理盐水处理的对照大鼠相似的方式重新获得对该条件刺激（CS）的恐惧。与对照组相比，DCS处理的大鼠展现出广泛的消退（即，它们对非消退的CS的恐惧较少）。[3] DCS是一种抗分枝杆菌剂，能够穿越血脑屏障，以高亲和力结合到这一甘氨酸调节位点，作为正向调节剂发挥作用，促进大鼠学习任务的表现。在抗菌活性所需剂量之下，DCS显现出强大的认知增强作用。[4] 在30次未强化的光曝光前，DCS注射（3.25、15或30 mg/kg）剂量依赖性地增强了消退，但不影响未接受消退训练的大鼠的恐惧增强惊跳。[5] |
| Synonyms | BAY1099, 米格列醇, BAY-m1099 |
| molecular weight | 207.22 |
| Molecular formula | C8H17NO5 |
| CAS | 72432-03-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: 20.7 mg/mL (100 mM) DMSO: 70 mg/mL (337.81 mM), Sonication is recommended. |
| References | 1. Rossi EJ, et al. FEBS J. 2006 Jun;273(12):2673-83. 2. Liu T, Liu R, Zhu L, et al. Development of a UHPLC-MS method for inhibitor screening against α-L-1, 3-fucosidase[J]. Analytical and bioanalytical chemistry. 2019 Mar;411(7):1467-1477. |
| Citations | 1. Liu T, Liu R, Zhu L, et al. Development of a UHPLC-MS method for inhibitor screening against α-L-1, 3-fucosidase. Analytical and bioanalytical chemistry. 2019 Mar;411(7):1467-1477. |