| Description | MIF098 is a macrophage migration inhibitory factor (MIF) antagonist.MIF098, inhibits pulmonary hypertension associated with SLE and inhibits pulmonary smooth muscle cell (PASMC) proliferation and migration.MIF098 may be used to study idiopathic pulmonary hypertension. |
| In vitro | 在浓度依赖性方面，MIF098（0-10 μM，48小时）通过阻断迁移抑制因子（MIF）途径，抑制mPASMC细胞的增殖和迁移[1]。通过抑制TGFβ1/Smad2/3途径，MIF098减少胶原蛋白的合成及肺动脉纤维化[1]。 |
| In vivo | 通过腹腔注射，每天一次，连续4周以40 mg/kg的剂量给予MIF098，可减缓C57BL/6J小鼠低氧诱导的肺动脉高压进展[1]。 |
| molecular weight | 255.27 |
| Molecular formula | C15H13NO3 |
| CAS | 1208448-95-6 |
| Storage | store under nitrogen | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (313.39 mM), Sonication is recommended. |
| References | 1. HuijingHuang, et al. The small molecule macrophage migration inhibitory factor antagonist MIF098, inhibits pulmonary hypertension associated with murine SLE. Int Immunopharmacol. 2019 Nov;76:105874. |