| Description | Metyrapone Tartrate is an inhibitor of the STEROID 11-beta-monooxygenase enzyme which is used as a test for feedback hypothalamic-pituitary mechanism in the diagnosis of Cushing SYNDROME. |
| Synonyms | SU 4885, Metopirone tartrate, SU-4885, SU4885 |
| molecular weight | 526.45 |
| Molecular formula | C22H26N2O13 |
| CAS | 908-35-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Weiler U, Finsler S, Claus R. Influence of cortisol, gonadal steroids and an energy deficit on biochemical indicators of bone turnover in Swine. J Vet Med A Physiol Pathol Clin Med. 2003 Mar;50(2):79-87. PubMed PMID: 12667198. 2. Dickstein G, Spindel A, Shechner C, Adawi F, Gutman H. Spontaneous remission in Cushing's disease. Arch Intern Med. 1991 Jan;151(1):185-9. Review. PubMed PMID: 1985595. 3. Mito T, Shiono T, Kimura R, Tamai M. The effect of oral metyrapone on aqueous humor dynamics in normal human eyes. Acta Ophthalmol (Copenh). 1990 Oct;68(5):582-6. PubMed PMID: 2275356. 4. Galinsky RE, Corcoran GB. Suppression of acetaminophen conjugation and of conjugate elimination in the rat by metyrapone, a classical P-450 inhibitor. Drug Metab Dispos. 1988 May-Jun;16(3):348-54. PubMed PMID: 2900724. |