| Description | Methylproamine is a DNA-binding radioprotector that repairs radiation-induced transient reactive oxygen species. |
| In vitro | 采用免疫细胞化学方法测量经过电离辐射（IR）后，患者来源的淋巴芽细胞内经Methylproamine处理的磷酸化H2AX（γH2AX）焦点积累情况。通过脉冲场凝胶电泳DNA损伤和修复检测直接评估Methylproamine 对辐照细胞DNA的影响。与未处理细胞相比，经Methylproamine 处理的细胞在IR后γH2AX焦点更少。同时，Methylproamine 的存在减少了进入凝胶的低分子量DNA的量[2]。 |
| molecular weight | 465.59 |
| Molecular formula | C28H31N7 |
| CAS | 188247-01-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (118.13 mM) |
| References | 1. Lobachevsky PN, Vasireddy RS, Broadhurst S, Protection by methylproamine of irradiated human keratinocytes correlates with reduction of DNA damage. Int J Radiat Biol. 2011 Mar;87(3):274-83. 2. Sprung CN, Vasireddy RS, Karagiannis TC, Methylproamine protects against ionizing radiation by preventing DNA double-strand breaks. Mutat Res. 2010 Oct 13;692(1-2):49-52. 3. Martin RF, Broadhurst S, Reum ME, In vitro studies with methylproamine: a potent new radioprotector. Cancer Res. 2004 Feb 1;64(3):1067-70. |