PeptideDB

Methyl Streptonigrin

CAS No.: 3398-48-9

Methyl Streptonigrin is an ABCG2 transporter function inhibitor.
Sales Email:peptidedb@qq.com

This product is for research use only, not for human use. We do not sell to patients.

Description Methyl Streptonigrin is an ABCG2 transporter function inhibitor.
Synonyms NSC 45384, NSC45384, NSC-45384
molecular weight 520.49
Molecular formula C26H24N4O8
CAS 3398-48-9
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Qian T, Wo J, Zhang Y, Song Q, Feng G, Luo R, Lin S, Wu G, Chen HF. Crystal Structure of StnA for the Biosynthesis of Antitumor Drug Streptonigrin Reveals a Unique Substrate Binding Mode. Sci Rep. 2017 Jan 11;7:40254. doi: 10.1038/srep40254. PubMed PMID: 28074848; PubMed Central PMCID: PMC5225493. 2. Kong D, Zou Y, Zhang Z, Xu F, Brock NL, Zhang L, Deng Z, Lin S. Identification of (2S,3S)-β-Methyltryptophan as the Real Biosynthetic Intermediate of Antitumor Agent Streptonigrin. Sci Rep. 2016 Feb 5;6:20273. doi: 10.1038/srep20273. PubMed PMID: 26847951; PubMed Central PMCID: PMC4742848. 3. Xia X, Lin S, Xia XX, Cong FS, Zhong JJ. Significance of agitation-induced shear stress on mycelium morphology and lavendamycin production by engineered Streptomyces flocculus. Appl Microbiol Biotechnol. 2014 May;98(10):4399-407. doi: 10.1007/s00253-014-5555-4. Epub 2014 Feb 13. PubMed PMID: 24522728. 4. Xu F, Kong D, He X, Zhang Z, Han M, Xie X, Wang P, Cheng H, Tao M, Zhang L, Deng Z, Lin S. Characterization of streptonigrin biosynthesis reveals a cryptic carboxyl methylation and an unusual oxidative cleavage of a N-C bond. J Am Chem Soc. 2013 Feb 6;135(5):1739-48. doi: 10.1021/ja3069243. Epub 2013 Jan 22. PubMed PMID: 23301954.