| Description | Methyl acetimidate is an effective in vitro antisickling agent. It has few detrimental effects on the red cell. |
| molecular weight | 73.09 |
| Molecular formula | C3H7NO |
| CAS | 14777-29-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Chao TL, Berenfeld MR. Prevention of the immune agglutination of methyl acetimidate-reacted sickle erythrocytes by prior reaction with pyridoxal 5'-phosphate. J Biol Chem. 1981 Jun 10;256(11):5324-6. PubMed PMID: 7240139. 2. Chao TL, Berenfeld MR, Gabuzda TG. Current status of methyl acetimidate as an extracorporeal antisickling agent. Am J Pediatr Hematol Oncol. 1984 Spring;6(1):55-8. PubMed PMID: 6711765. 3. Richardson VB, Littlefield LG, Colyer SP. Cytogenetic evaluations in human lymphocytes exposed to methyl acetimidate, a lysine-specific protein crosslinking agent. Mutat Res. 1987 Sep;180(1):121-9. PubMed PMID: 3114624. 4. Chao TL, Berenfeld MR, Gabuzda TG. Protection of erythrocyte membrane amino groups from reaction with methyl acetimidate by pyridoxal 5'-phosphate Schiff base formation. Biochim Biophys Acta. 1984 Apr 11;771(2):183-7. PubMed PMID: 6704394. |