| Description | Methyl 3-O-methylgallate (M3OMG) is a rare natural product that showed promising antioxidant activities. |
| In vitro | Methyl 3-O-methylgallate 在神经SH-SY5Y细胞[2]中显示了抗氧化活性，并未表现出促氧化效应。 |
| In vivo | 动物分别用Methyl 3-O-methylgallate（10和20 mg/kg i.p.）、维生素C（10 mg/kg i.p.）作为标准抗氧化剂或载体（5% 二甲基亚砜；1 ml/kg）处理1周。通过在饮用水中添加600 ppm NaF连续7天，诱导大脑产生氧化应激。治疗周期结束时，检测大脑匀浆中硫代巴比妥酸活性物质（TBARS）、还原型谷胱甘肽的水平以及抗氧化酶（超氧化物歧化酶和过氧化氢酶）的活性。Methyl 3-O-methylgallate通过正常化TBARS水平、降低还原型谷胱甘肽水平以及恢复减少的抗氧化酶活性，减轻了NaF诱导的氧化应激[1]。 |
| Synonyms | 3,4-二羟基-5-甲氧基苯甲酸甲酯, M3OMG |
| molecular weight | 198.17 |
| Molecular formula | C9H10O5 |
| CAS | 3934-86-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (252.31 mM) |
| References | 1. Nabavi SF, et al. Neuroprotective effects of methyl-3-O-methyl gallate against sodium fluoride-induced oxidative stress in the brain of rats. Cell Mol Neurobiol. 2013 Mar;33(2):261-7. 2. Habtemariam S. Methyl-3-O-methyl gallate and gallic acid from the leaves of Peltiphyllum peltatum: isolation and comparative antioxidant, prooxidant, and cytotoxic effects in neuronal cells. J Med Food. 2011 Nov;14(11):1412-8. |