| Description | Methotrexate 1-methyl ester is an impurity of Methotrexate which is a folic acid antagonist. It's used as an antineoplastic and antirheumatic. |
| Synonyms | Methotrexate related compound I, Methotrexate alpha-methyl ester |
| molecular weight | 468.47 |
| Molecular formula | C21H24N8O5 |
| CAS | 66147-29-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Henderson GB, Tsuji JM. Methotrexate efflux in L1210 cells. Kinetic and specificity properties of the efflux system sensitive to bromosulfophthalein and its possible identity with a system which mediates the efflux of 3',5'-cyclic AMP. J Biol Chem. 1987 Oct 5;262(28):13571-8. PubMed PMID: 2820975. 2. Gewirtz DA, Randolph JK, Jaramillo M. Induction of methotrexate release from rat hepatocytes in suspension by alpha-adrenergic agents: involvement of calcium and metabolic energy. Arch Biochem Biophys. 1985 Feb 15;237(1):237-43. PubMed PMID: 2578767. |