| Description | Methazolamide (CL 8490) is a carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma. |
| In vitro | 在麻醉的兔子体内,Methazolamide不损害呼吸功能. |
| In vivo | Methazolamide是一种碳酸酐酶抑制剂,可抑制hCA I（Ki：50 nM）,hCA II（Ki：14 nM）和bCA IV（Ki：36 nM）亚型。 |
| Target activity | CA I (human):50 nM(Ki), CA IV (bovine):36 nM(Ki), CA II (human):14 nM(Ki) |
| Synonyms | L584601, 醋甲唑胺, CL 8490 |
| molecular weight | 236.27 |
| Molecular formula | C5H8N4O3S2 |
| CAS | 554-57-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | H2O: < 1 mg/mL (insoluble or slightly soluble) DMSO: 60 mg/mL (253.95 mM) Ethanol: 3 mg/mL (12.69 mM) |
| References | 1. Casini A, et al. Bioorg Med Chem Lett, 2003, 13(5), 841-845. 2. Kiwull-Schöne HF, et al. Am J Physiol Regul Integr Comp Physiol, 2009, 297(3), R648-654. 3. Pocker Y, et al. Biochemistry, 1967, 6(3), 668-678. |