| Description | Methapyrilene is a histamine H1 antagonist with sedative action. |
| Synonyms | Lulamin, Histase, Thenylene, Pyrahistidin, Dormin |
| molecular weight | 261.39 |
| Molecular formula | C14H19N3S |
| CAS | 91-80-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Inoue K, Ochi A, Koda A, Wako Y, Kawasako K, Doi T. The 14-day repeated dose liver micronucleus test with methapyrilene hydrochloride using young adult rats. Mutat Res Genet Toxicol Environ Mutagen. 2015 Mar;780-781:123-7. doi: 10.1016/j.mrgentox.2014.04.004. Epub 2014 Apr 24. PubMed PMID: 24768639. 2. Winek CL, Fochtman FW, Trogus WJ Jr, Fusia EP, Shanor SP. Methapyrilene toxicity. Clin Toxicol. 1977;11(3):287-94. PubMed PMID: 913071. 3. Ratra GS, Cottrell S, Powell CJ. Effects of induction and inhibition of cytochromes P450 on the hepatotoxicity of methapyrilene. Toxicol Sci. 1998 Nov;46(1):185-96. PubMed PMID: 9928682. 4. Iype PT, Ray-Chaudhuri R, Lijinsky W, Kelley SP. Inability of methapyrilene to induce sister chromatid exchanges in vitro and in vivo. Cancer Res. 1982 Nov;42(11):4614-8. PubMed PMID: 7127299. |