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Mepyramine

CAS No.: 91-84-9

Mepyramine is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used fo
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Description Mepyramine is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies both parenterally and locally.
Synonyms NSC-13136, NSC13136, NSC 13136
molecular weight 285.38
Molecular formula C17H23N3O
CAS 91-84-9
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility DMSO: 55 mg/ml (192.72 mM)
References 1. Jain S, Panyutin A, Liu N, Xiao C, Piñol RA, Pundir P, Girardet C, Butler AA, Dong X, Gavrilova O, Reitman ML. Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors. Am J Physiol Endocrinol Metab. 2018 May 29. doi: 10.1152/ajpendo.00024.2018. [Epub ahead of print] PubMed PMID: 29812984. 2. Alachkar A, Latacz G, Siwek A, Lubelska A, Honkisz E, Gryboś A, Łażewska D, Handzlik J, Stark H, Kiec-Kononowicz K, Sadek B. Anticonvulsant evaluation of novel non-imidazole histamine H3R antagonists in different convulsion models in rats. Pharmacol Biochem Behav. 2018 May 3;170:14-24. doi: 10.1016/j.pbb.2018.04.010. [Epub ahead of print] PubMed PMID: 29729290. 3. Kennedy L, Hargrove L, Demieville J, Karstens A, Jones H, DeMorrow S, Meng F, Invernizzi P, Bernuzzi F, Alpini G, Smith S, Akers A, Meadows V, Francis H. Blocking H1/H2 histamine receptors inhibits damage/fibrosis in Mdr2(-/-) mice and human cholangiocarcinoma tumorigenesis. Hepatology. 2018 Mar 30. doi: 10.1002/hep.29898. [Epub ahead of print] PubMed PMID: 29601088. 4. Popiolek-Barczyk K, Łażewska D, Latacz G, Olejarz A, Makuch W, Stark H, Kieć-Kononowicz K, Mika J. Antinociceptive effects of novel histamine H(3) R and H(4) R receptor antagonists and their influence on morphine analgesia of neuropathic pain in the mouse. Br J Pharmacol. 2018 Feb 27. doi: 10.1111/bph.14185. [Epub ahead of print] PubMed PMID: 29486058.