| Description | Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) is used clinically in China to treat hemorrhagic diseases caused by vitamin K deficiency and globally as a vitamin K supplement. |
| In vitro | MSB以剂量依赖的方式抑制了Aβ42淀粉样蛋白的形成，延缓了Aβ42从随机卷曲到有序β-折叠的二级结构转变，并减弱了Aβ42聚集体破坏膜的能力；此外，MSB的抑制效应主要由醌骨架而非亲脂性决定。在表达致病性APP突变（大阪突变）的细胞中，导致神经元内Aβ寡聚体形成的情况下，MSB抑制了Aβ的细胞内聚集。此外，MSB处理显著延长了表达人Aβ42的秀丽隐杆线虫CL2120株的寿命。这些结果一起表明，MSB及其衍生物可作为预防或治疗阿尔兹海默病（AD）的潜在治疗剂进一步探索[1]。 |
| Synonyms | Sodium menadione bisulfite, 亚硫酸氢钠甲萘醌, Menadione sodium bisulfite, Vitamin K3 sodium bisulfite |
| molecular weight | 276.24 |
| Molecular formula | C11H9NaO5S |
| CAS | 130-37-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 20 mg/mL (72.4 mM), Sonication is recommended. |
| References | 1. Yu Z , Yudan Z , Zhuoyi W , et al. Menadione sodium bisulfite inhibits the toxic aggregation of amyloid-β(1–42)[J]. Biochimica et Biophysica Acta (BBA) - General Subjects, 2018, 1862(10):2226-2235. 2. Astakhova T , Morozov A , Erokhov P , et al. Combined Effect of Bortezomib and Menadione Sodium Bisulfite on Proteasomes of Tumor Cells: The Dramatic Decrease of Bortezomib Toxicity in a Preclinical Trial[J]. Cancers, 2018, 10(10). |