| Description | MenA-IN-2 is a potent 1, 4-dihydroxy-2-naphthoate isopentadiene transferase (MenA) inhibitor with an IC50 value of 22 µM for MenA and 10 µM for Mycobacterium tuberculosis (Mtb). The continuous transmission of MenA-IN-2 Mtb has inhibitory effect. |
| Target activity | MenA:22 µM |
| molecular weight | 386.96 |
| Molecular formula | C23H31ClN2O |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 225.0 mg/mL (581.5 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Berg K, et al. SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. Eur J Med Chem. 2023;249:115125. |