| Description | Melittin TFA is a small protein containing 26 amino acid residues, is the principal toxic component of bee venom. Melittin is a PLA2 activator, stimulates the activity of the low molecular weight PLA2, while it does not the increase activity of the high molecular weight PLA2. |
| In vitro | Melittin（来自蜜蜂毒液的免疫相关PLA2刺激肽）增加了高分子量酶的活性[1]。Melittin是一种蜜蜂毒液中的细胞毒性肽，对A2780CR和A2780细胞表现出毒性，IC50值分别为4.5和6.8μg/mL。Melittin具有天然的抗细菌、抗病毒和抗炎特性。此外，Melittin在多种癌细胞系中显示出多样化的抗癌效果，包括胃癌、乳腺癌、卵巢癌、肝癌、前列腺癌、宫颈癌和肺癌等。Melittin作为一种两亲性溶血肽，其潜在的抗癌效果机制包括抑制细胞增殖、诱导凋亡和直接坏死。Melittin还能通过抑制PI3K/Akt/mTOR信号通路阻止EGF诱导的细胞侵袭，这主要与乳腺癌细胞相关[2]。 |
| molecular weight | 2960.54 |
| Molecular formula | C133H230F3N39O33 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 5 mM H2O: 20 mM |
| References | 1. Steiner MR, et al. Responses of purified phospholipases A2 to phospholipase A2 activating protein (PLAP) and Melittin. Biochim Biophys Acta. 1993 Feb 10;1166(1):124-30. |