| Description | MEL24, an Mdm2 E3 ligase inhibitor, diminishes cell viability and enhances sensitivity to DNA-damaging agents in a p53-dependent manner, suggesting its potential for in vitro antitumor research [1]. |
| In vitro | MEL24 对293T细胞的ED 50 为9.2μM[1]。与此同时，MEL24（15μM，6小时）可以升高Mdm2、p53和MdmX蛋白水平，激活p53，并在HCT116细胞（p53野生型）中阻断内源性MdmX的降解[1]。 |
| molecular weight | 326.35 |
| Molecular formula | C17H18N4O3 |
| CAS | 642072-48-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |