| Description | Mefloquine (Ro 215998), a quinoline antimalarial agent, is an anti-SARS-CoV-2 entry inhibitor. Mefloquine is also a K+ channel (KvQT1/minK) antagonist with an IC50 of ~1 μM. Mefloquine can be used for malaria, systemic lupus erythematosus, and cancer research. |
| Synonyms | Ro215998, WR 142490, Ro-215998, 氟甲喹羟哌啶, Lariam, Ro 215998 |
| molecular weight | 378.31 |
| Molecular formula | C17H16F6N2O |
| CAS | 53230-10-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/ml (145.38 mM) |
| References | 1. Kang J, et al. Interactions of the antimalarial drug mefloquine with the human cardiac potassium channels KvLQT1/minK andHERG. J Pharmacol Exp Ther. 2001 Oct;299(1):290-6. 2. Janowsky A, Eshleman AJ, Johnson RA, Wolfrum KM, Hinrichs DJ, Yang J, Zabriskie TM, Smilkstein MJ, Riscoe MK. Mefloquine and psychotomimetics share neurotransmitter receptor and transporter interactions in vitro. Psychopharmacology (Berl). 2014 Jul;231(14):2771-83. doi: 10.1007/s00213-014-3446-0. Epub 2014 Feb 2. PubMed PMID: 24488404; PubMed Central PMCID: PMC4097020. 3. Tao Y, Xue J, Jiang B, Zhang HB, Xiao SH. Significance of higher drug concentration in erythrocytes of mice infected with Schistosoma japonicum and treated orally with mefloquine at single doses. Parasitol Res. 2015 Dec;114(12):4521-30. doi: 10.1007/s00436-015-4696-4. Epub 2015 Sep 4. PubMed PMID: 26341799. 4. Maaswinkel H, Zhu L, Weng W. A small-fish model for behavioral-toxicological screening of new antimalarial drugs: a comparison between erythro- and threo-mefloquine. BMC Res Notes. 2015 Apr 2;8:122. doi: 10.1186/s13104-015-1088-x. PubMed PMID: 25886204; PubMed Central PMCID: PMC4386100. |