| Description | (+)-Medioresinol possesses antioxidative, a lesishmanicidal activity and cardiovascular disease risk reduction, it has antiamyloidogenic activity via reduction in the amount of α2-secretase, it is a potentially valuable antiamyloidogenic agent for the prevention and treatment of Alzheimer disease. (+)-Medioresinol has anti-bacterial, antifungal and anti-biofilm activities. |
| In vitro | Antibacterial effects of (+)-Medioresinol isolated from stem bark of Sambucus williamsii and its synergistic activities in combination with antibiotics such as ampicillin, cefotaxime, and chloramphenicol were tested by antibacterial susceptibility testing and checkerboard assay. (+)-Medioresinol possessed antibacterial effects against antibiotics-susceptible- or antibiotics-resistant strains. Most of combinations between (+)-Medioresinol and each antibiotic showed synergistic interaction (fractional inhibitory concentration index ?≤ 0.5) against bacterial strains including antibiotics-resistant Pseudomonas aeruginosa. Furthermore, the antibiofilm effect of (+)-Medioresinol alone or in combination with each antibiotic was investigated[1] |
| Synonyms | 梣皮树脂醇, 皮树脂醇, Medioresinol |
| molecular weight | 388.41 |
| Molecular formula | C21H24O7 |
| CAS | 40957-99-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Synergistic antibacterial and antibiofilm effect between (+)-medioresinol and antibiotics in vitro.Appl Biochem Biotechnol. 2013 Aug;170(8):1934-41. |