| Description | MDX-1342, a fully human monoclonal antibody (HuMAb), targets the CD19 membrane receptor with high specificity and affinity. It exhibits antibody-dependent cellular cytotoxicity (ADCC) and is utilized in researching B-lymphocyte malignancies and autoimmune diseases [1]. |
| In vitro | MDX-1342（0-100 μg/mL；30分钟）对Ramos、Raji及ARH-77细胞展示出结合活性，其EC 50 值为0。 |
| In vivo | MDX-1342（静脉注射；0.03、0.3、3及30 mg/kg；200 μL）在小鼠B细胞淋巴瘤模型中显示出剂量依赖性的生存改善效果[1]。MDX-1342（静脉注射；0.1或1 mg/kg；单次）对狨猴CD19具有低纳摩尔级别的结合能力，增强了对狨猴FcyRllla的亲和力，并在体内显现出强大的B细胞耗竭作用[1]。 |
| molecular weight | N/A |
| CAS | 1646327-65-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 years | Shipping with blue ice. |