| Description | MDK-4683, also known as CA IX/XII Inhibitor, is a hCA IX and hCA XII inhibitor. |
| Synonyms | MDK 4683, CA IX/XII Inhibitor |
| molecular weight | 336.32 |
| Molecular formula | C13H12N4O5S |
| CAS | 175014-68-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Pustenko A, Stepanovs D, Žalubovskis R, Vullo D, Kazaks A, Leitans J, Tars K, Supuran CT. 3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem. 2017 Dec;32(1):767-775. doi: 10.1080/14756366.2017.1316720. PubMed PMID: 28537099. 2. Carta F, Vullo D, Osman SM, AlOthman Z, Supuran CT. Synthesis and carbonic anhydrase inhibition of a series of SLC-0111 analogs. Bioorg Med Chem. 2017 May 1;25(9):2569-2576. doi: 10.1016/j.bmc.2017.03.027. Epub 2017 Mar 18. PubMed PMID: 28347633. 3. Nocentini A, Carta F, Ceruso M, Bartolucci G, Supuran CT. Click-tailed coumarins with potent and selective inhibitory action against the tumor-associated carbonic anhydrases IX and XII. Bioorg Med Chem. 2015 Nov 1;23(21):6955-66. doi: 10.1016/j.bmc.2015.09.041. Epub 2015 Sep 28. PubMed PMID: 26432607. 4. Sarikaya B, Ceruso M, Carta F, Supuran CT. Inhibition of carbonic anhydrase isoforms I, II, IX and XII with novel Schiff bases: identification of selective inhibitors for the tumor-associated isoforms over the cytosolic ones. Bioorg Med Chem. 2014 Nov 1;22(21):5883-90. doi: 10.1016/j.bmc.2014.09.021. Epub 2014 Sep 21. PubMed PMID: 25267005. |