| Description | MCI-225 is a selective inhibitor of NA reuptake with 5-HT3 receptor antagonism. |
| In vivo | MCI-225 (10 mg/kg, po) showed comparable anxiolytic-like effect between single and 5-day repeated administration. |
| molecular weight | 328.4 |
| Molecular formula | C17H17FN4S |
| CAS | 135991-48-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: Slightly soluble |
| References | 1. Eguchi J , Inomata Y , Saito K I . The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism[J]. Pharmacology Biochemistry & Behavior, 2001, 68(4):677-683. 2. Junichi Eguchi, Kunihisa Iwai, Takayuki Yuasa,et al. Effects of MCI-225 on memory and glucose utilization in basal forebrain-lesioned rats[J]. Pharmacology Biochemistry and Behavior, 1995, 51(4):935-939. |