| Description | Maresin 1 is a small molecule compound biosynthesized by macrophages (MΦ) with significant anti-inflammatory activity that attenuates LPS-induced lung injury in mice by inhibiting neutrophil adhesion and decreasing the levels of pro-inflammatory cytokines, and stimulates intracellular Ca2+ production and secretion. |
| In vitro | 除了降低IL-1β、TNF-α、IL-6和INF-γ的产生外，Maresin 1 (MaR1, 300 nM) 还减少中性粒细胞迁移和活性氧物质的生成[2]。 |
| In vivo | In a dose-dependent manner, Maresin 1 (MaR1) inhibits TRPV1 currents in neurons, blocking capsaicin-induced inward currents (IC50=0.49 nM), and alleviates inflammation and chemotherapy-induced neuropathic pain in mice [3].Maresin 1 (MaR1, 0.1, 0.3, and 1 μg/animal, iv) protects mice from acute DSS-induced colitis. Treatment with Maresin 1 (0.3 and 1 μg/animal, iv) significantly reduces macroscopic damage in the acute phase of DSS-induced colitis [2]. |
| molecular weight | 360.49 |
| Molecular formula | C22H32O4 |
| CAS | 1268720-28-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMF: 50 mg/mL PBS (pH 7.2): 0.05 mg/mL Ethanol: 40 mg/mL(110.95 mM), Sonication is recommended. DMSO: 40 mg/mL(110.95 mM), Sonication is recommended. |
| References | 1. Olsen MV,et al. Maresin 1, a specialized proresolving mediator, stimulates intracellular [Ca2+ ] and secretion in conjunctival goblet cells. J Cell Physiol. 2021 Jan;236(1):340-353. 2. Rodrigo Marcon, et al. Maresin 1, a Proresolving Lipid Mediator Derived From omega-3 Polyunsaturated Fatty Acids, Exerts Protective Actions in Murine Models of Colitis. J Immunol. 2013 Oct 15;191(8):4288-98. 3. Serhan CN, et al. Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J. 2012 Apr;26(4):1755-65. 4. Serhan, C. . (2007). |