| Description | MAO-B-IN-22 (compound 6h) represents a powerful MAO-B inhibitor, boasting an IC50 value of 0.014 μM, and exhibits high antioxidant activity alongside effective metal-chelating properties. It also demonstrates adequate BBB permeability and notable neuroprotective effects [1]. |
| In vitro | MAO-B-IN-22（化合物6h）在2.5-50 μM浓度范围内，24小时处理可以剂量依赖性地防御过氧化氢引起的氧化损伤，增强细胞活性[1]。同一化合物，在0.5-10 μM浓度下，24小时处理能剂量依赖性地减少LPS诱发的NO产生，表现出抗神经炎症活性[1]。 |
| In vivo | MAO-B-IN-22（化合物6h）（53.5 mg/kg，经口灌胃，每天一次，连续3周）通过抑制MAO-B，提高小鼠多巴胺能神经递质水平及减少ROS导致的氧化伤害，从而缓解MPTP处理的小鼠运动障碍，并有可能改善体内帕金森病（PD）症状[1]。 |
| molecular weight | 323.36 |
| Molecular formula | C20H18FNO2 |
| CAS | 2902600-76-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |