| Description | Manganese(salen) chloride (EUK-8) (EUK-8) is a superoxide dismutase and catalase mimetic. Manganese(salen) chloride (EUK-8) is an antioxidant with oxyradical scavenging properties. Manganese(salen) chloride ameliorates acute lung injury in endotoxemic swine. |
| In vitro | Manganese(salen) chloride（25 μM；24-72小时）能保护器官型海马切片免受β-AP诱导的神经毒性，同时完全阻断β-AP诱发的自由基积累和脂质过氧化[2]。 |
| In vivo | Manganese(salen) chloride （25 mg/kg；每周三次，连续四周腹腔注射）能减少心脏氧化应激并改善哈里奎因小鼠突变体因压力超负荷引起的心力衰竭[3]。动物模型：野生型（WT）和哈里奎因（Hq）B6CBA雄性及雌性小鼠[3]。剂量：25 mg/kg/天。给药方式：每周三次，连续四周腹腔注射。结果：预防了由生物力学应力引起的心肌氧化损伤，提高了生物力学应力后的存活率，预防了压力超负荷响应时的功能和几何退化，减轻了坏死和凋亡细胞死亡，以及减轻了心脏肥大和纤维化。此外，因为抗氧化剂治疗保护了易受氧化应激影响的Hq小鼠模型和WT小鼠免受压力超负荷诱导的不良左心室重塑和心脏衰竭，它可能作为治疗人类心力衰竭的新型治疗工具。 |
| Synonyms | EUK-8 |
| molecular weight | 356.69 |
| Molecular formula | C16H14ClMnN2O2 |
| CAS | 53177-12-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 8.33 mg/mL (23.35 mM), Sonication is recommended. |
| References | 1. Gonzalez PK, et, al. EUK-8, a synthetic superoxide dismutase and catalase mimetic, ameliorates acute lung injury in endotoxemic swine. J Pharmacol Exp Ther. 1995 Nov;275(2):798-806. 2. Bruce AJ, et, al. beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger. Proc Natl Acad Sci U S A. 1996 Mar 19;93(6):2312-6. 3. Empel VPM, et, al. EUK-8, a superoxide dismutase and catalase mimetic, reduces cardiac oxidative stress and ameliorates pressure overload-induced heart failure in the harlequin mouse mutant. J Am Coll Cardiol. 2006 Aug 15;48(4):824-32. |