| Description | Malonganenone A is a selective plasmodial Hsp70s modulator. It also has antimalarial activity. |
| Synonyms | Malonganenone-A, Malonganenone-E, Malonganenone E |
| molecular weight | 438.61 |
| Molecular formula | C26H38N4O2 |
| CAS | 882403-69-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Cockburn IL, Boshoff A, Pesce ER, Blatch GL. Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. Biol Chem. 2014 Nov 1;395(11):1353-62. doi: 10.1515/hsz-2014-0138. PubMed PMID: 24854538. 2. Clark PG, Lein M, Keyzers RA. Studies of the H-D exchange mechanism of malonganenone B. Org Biomol Chem. 2012 Mar 7;10(9):1725-9. doi: 10.1039/c2ob06926a. Epub 2012 Jan 16. PubMed PMID: 22246312. 3. Cockburn IL, Pesce ER, Pryzborski JM, Davies-Coleman MT, Clark PG, Keyzers RA, Stephens LL, Blatch GL. Screening for small molecule modulators of Hsp70 chaperone activity using protein aggregation suppression assays: inhibition of the plasmodial chaperone PfHsp70-1. Biol Chem. 2011 May;392(5):431-8. doi: 10.1515/BC.2011.040. Epub 2011 Mar 23. PubMed PMID: 21426241. |