| Description | Malic enzyme inhibitor ME1 (ME1) is a specific inhibitor of Malic enzyme (IC50 = 0.15 μM). Malic enzyme inhibitor ME1 reduces cell viability/metabolic activity. |
| In vitro | 在HCT116细胞和HT29细胞中，Malic enzyme inhibitor ME1（50 μM）显著且剂量依赖性地降低了细胞总数和细胞集落数量。在MTS细胞中，Malic enzyme inhibitor ME1减少了细胞的活力和代谢活性[2]。 |
| Target activity | Malic enzyme:0.15 μM |
| Synonyms | ME1 |
| molecular weight | 351.4 |
| Molecular formula | C20H21N3O3 |
| CAS | 522649-59-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 90.0 mg/mL (256.1 mM), Sonication and heating to 60℃ are recommended. |
| References | 1. Zhang YJ, et al. In silico design and synthesis of piperazine-1-pyrrolidine-2,5-dione scaffold-based novel malic enzyme inhibitors. Bioorg Med Chem Lett. 2006 Feb;16(3):525-8. Epub 2005 Nov 8. 2. Fernandes L, et al. Malic Enzyme 1 (ME1) is pro-oncogenic in ApcMin/+ mice. Sci Rep. 2018 Sep 24;8(1):14268. |