| Description | Maclurin (NSC-83240) is a phenolic component of mulberry twigs, exerts anti-metastatic effects. Maclurin effectively protects against OH-induced damages to DNA and MSCs and can be used in studies about the prevention of many diseases or MSCs transplantation. |
| In vitro | Maclurin effectively protects against mesenchymal stem cells (MSCs) oxidative damage induced by hydroxyl radical (OH) at 62.1-310.5 μM. Maclurin efficiently protects DNA from OH-induced damage at 114.6-382.2 μM, and scavenge OH, DPPH, ABTS(+), and bind Cu(2+) with IC50s of 122.87, 10.15, 0.97, and 133.95 μM[1]. |
| Synonyms | Fustic extract, Morintannic acid, NSC 83240 |
| molecular weight | 262.21 |
| Molecular formula | C13H10O6 |
| CAS | 519-34-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.8 mg/mL (18.31 mM) |
| References | 1. Li X, et al. Maclurin protects against hydroxyl radical-induced damages to mesenchymal stem cells: antioxidant evaluation and mechanistic insight. Chem Biol Interact. 2014 Aug 5;219:221-8. 2. Ku MJ, et al. Maclurin suppresses migration and invasion of human non-small-cell lung cancer cells via anti-oxidative activity and inhibition of the Src/FAK-ERK-β-catenin pathway. Mol Cell Biochem. 2015 Apr;402(1-2):243-52. 3. Lee YJ, Lee SY. Maclurin exerts anti-cancer effects in human osteosarcoma cells via prooxidative activity and modulations of PARP, p38, and ERK signaling. IUBMB Life. 2021 Aug;73(8):1060-1072. 4. Kim J, et al. Protective Effects of Maclurin against Benzo[a]pyrene via Aryl Hydrocarbon Receptor and Nuclear Factor Erythroid 2-Related Factor 2 Targeting. Antioxidants (Basel). 2021 Jul 26;10(8):1189. |