| Description | M1145 acetate, a chimeric peptide, is a selective galanin receptor type 2 (GAL2) agonist, with a Ki of 6.55 nM. M1145 acetate shows more than 90-fold higher affinity for GAL2 over GAL1 (Ki=587 nM) and a 76-fold higher affinity over GalR3 (Ki=497 nM). M1145 acetate has an additive effect on the signal transduction of galanin[1]. |
| In vitro | M1145 acetate在促进胆碱信号转导方面具有增效作用，其浓度在0.1μM及以上时能达到最大信号转导。通过评估其在表达GalR2的CHO细胞中刺激肌醇磷酸(IP)产生的能力来检查信号转导。使用M1145 acetate处理可以刺激IP产生，其EC50为38nM[1]。 |
| molecular weight | 2834.28 |
| Molecular formula | C130H209N37O34 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Runesson J, Saar I, Lundström L, Järv J, Langel U. A novel GalR2-specific peptide agonist. Neuropeptides. 2009;43(3):187-192. |