| Description | Lysine-methotrexate is an anticancer drug. It is an inhibitor of dihydrofolate reductase. |
| Synonyms | ADMPL |
| molecular weight | 453.5 |
| Molecular formula | C21H27N9O3 |
| CAS | 80407-56-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Singh VK, Subudhi BB. Development and characterization of lysine-methotrexate conjugate for enhanced brain delivery. Drug Deliv. 2016 Sep;23(7):2327-2337. Epub 2014 Dec 5. PubMed PMID: 25475953. 2. Díaz E, Köhidai L, Ríos A, Vanegas O, Silva A, Szabó R, Mező G, Hudecz F, Ponte-Sucre A. Leishmania braziliensis: cytotoxic, cytostatic and chemotactic effects of poly-lysine-methotrexate-conjugates. Exp Parasitol. 2013 Sep;135(1):134-41. doi: 10.1016/j.exppara.2013.06.007. Epub 2013 Jun 28. PubMed PMID: 23816643. 3. Kempton RJ, Black AM, Anstead GM, Kumar AA, Blankenship DT, Freisheim JH. Lysine and ornithine analogues of methotrexate as inhibitors of dihydrofolate reductase. J Med Chem. 1982 Apr;25(4):475-7. PubMed PMID: 7069726. |