| Description | Ly93 is a selective and orally active sphingomyelin synthase 2 (SMS2) inhibitor (IC50: 91 nM) for the study of atherosclerosis. |
| In vivo | 在 C57BL/6J 小鼠上进行的 Ly93 药代动力学特征表明 Ly93 口服有效。作为一种有效的选择性 SMS2 抑制剂，Ly93(100 mg/kg, i.g. once daily for 7 days) 显著降低了 C57BL/6J 小鼠的血浆 SM 水平[1]。 |
| molecular weight | 332.4 |
| Molecular formula | C21H20N2O2 |
| CAS | 1883528-69-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 80 mg/mL (240.67 mM), Sonication is recommended. |
| References | 1. Li Y, et al. Discovery, synthesis and anti-atherosclerotic activities of a novel selective sphingomyelin synthase 2 inhibitor. Eur J Med Chem. 2019 Feb 1;163:864-882. |