| Description | LY 97241 is an inhibitor of hEAG1 and hERG1 potassium channel. |
| Synonyms | LY-97241, LY97241 |
| molecular weight | 320.47 |
| Molecular formula | C19H32N2O2 |
| CAS | 72456-63-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Gessner G, Zacharias M, Bechstedt S, Schönherr R, Heinemann SH. Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents. Mol Pharmacol. 2004 May;65(5):1120-9. PubMed PMID: 15102940. 2. Gessner G, Heinemann SH. Inhibition of hEAG1 and hERG1 potassium channels by clofilium and its tertiary analogue LY97241. Br J Pharmacol. 2003 Jan;138(1):161-71. PubMed PMID: 12522086; PubMed Central PMCID: PMC1573651. 3. Finlayson K, Turnbull L, January CT, Sharkey J, Kelly JS. [3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen. Eur J Pharmacol. 2001 Oct 26;430(1):147-8. PubMed PMID: 11698075. 4. Steidl JV, Yool AJ. Distinct mechanisms of block of Kv1.5 channels by tertiary and quaternary amine clofilium compounds. Biophys J. 2001 Nov;81(5):2606-13. PubMed PMID: 11606274; PubMed Central PMCID: PMC1301728. |