| Description | LY541850 is a selective orthosteric mGlu2 agonist and mGlu3 antagonist with IC50 values of 0.161 μM and 0.038 μM, respectively.LY 541850 is claimed from human ionotropic and metabotropic glutamate (mGlu) receptors expressed in non-neuronal cells. |
| In vivo | LY 541850 (intraperitoneal injection;?10 mg/kg-300 mg/kg;?30 min prior) reduces the increased locomotor activity of phencyclidine and amphetamine in a dose-dependent manner in male ICR mice[1]. |
| Target activity | mGluR3:1.05 μM, mGluR2:0.161 μM |
| molecular weight | 199.2 |
| Molecular formula | C9H13NO4 |
| CAS | 852679-76-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hanna L, et al. Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist. Neuropharmacology. 2013 Mar;66:114-21. |