| Description | LY 295427 is a bioactive chemical. |
| molecular weight | 428.73 |
| Molecular formula | C30H52O |
| CAS | 152755-31-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Bielska AA, Olsen BN, Gale SE, Mydock-McGrane L, Krishnan K, Baker NA, Schlesinger PH, Covey DF, Ory DS. Side-chain oxysterols modulate cholesterol accessibility through membrane remodeling. Biochemistry. 2014 May 13;53(18):3042-51. doi: 10.1021/bi5000096. Epub 2014 May 1. PubMed PMID: 24758724; PubMed Central PMCID: PMC4020583. 2. Bielska AA, Ory DS, Covey DF. Synthesis of the enantiomer of the oxysterol-antagonist LY295427. Steroids. 2011 Sep-Oct;76(10-11):986-90. doi: 10.1016/j.steroids.2011.03.008. Epub 2011 Apr 4. PubMed PMID: 21470559; PubMed Central PMCID: PMC3139699. 3. Nunomura S, Endo K, Makishima M, Ra C. Oxysterol represses high-affinity IgE receptor-stimulated mast cell activation in Liver X receptor-dependent and -independent manners. FEBS Lett. 2010 Mar 19;584(6):1143-8. doi: 10.1016/j.febslet.2010.02.006. Epub 2010 Feb 9. PubMed PMID: 20138879. 4. Borthwick F, Taylor JM, Bartholomew C, Graham A. Differential regulation of the STARD1 subfamily of START lipid trafficking proteins in human macrophages. FEBS Lett. 2009 Apr 2;583(7):1147-53. doi: 10.1016/j.febslet.2009.02.042. Epub 2009 Mar 10. PubMed PMID: 19272380. |